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The Nursing Knowledge Big Data Science Conference brings together nurse leaders and informaticists from public and private institutions and organizations across the United States and beyond to discuss the improvement of health and healthcare by using nursing knowledge empowered by data and informatics. This year, the conference will continue to explore artificial intelligence and successful large-scale nursing research. Specifically, we will boost discussion around social determinants of health (SDOH), and how SDOH data can inform care practice through the incorporation of advanced analytics.